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- W2369589039 abstract "Objective To observe the effect of application of Sirolimus on adventitia in preventing stenosis of vein graft. Methods Twelve dog jugular vein grafting models were made by transplanting self-jugular vein to bikteral femoral artery. The vein grafts of the treated side were smeared by Sirolimus fibrin glue (200 μg/2 ml) and those of the control side only by fibrin glue without Sirolimus. Six dog vein grafts were harvested at 2nd and 4th week after operation respectively. The intimal thickness and sectional area in the vein grafts were calculated by computer image analysis system, PCNA detected by immuno-histochemistry and ultrastructural changes were observed under scanning electron microscopy. Results The intimal thickness was thinner and intimal sectional area less on the treated side [(168.93 ± 50.18) μm and (175.93±54.17) μm and (1.08±0.20) mm2 and (1.23± 0.34) mm2respectively] than those on the control side [(201.83 ±?43.57) μm and (224.83±45.92) μm and (1.48± 0.11) mm2 and (1.71±0.15) mm2 respectively, P0.05].The PCNAI in vascular wall on the treated side was lower than on the control side (14.78±1.89 vs 23.56±1.87, P 0.05) 2 weeks after surgery, but there was no significant difference between the two groups 4 weeks after surgery. By means of scanning electron microscopy, the endothelial overlayer arranged well in the samples of treated side 2 weeks after surgery. On postoperative week 4, the intima in the two groups was covered by endothelium completely. Conclusion Local application of Sirolimus on adventitia is effective in preventing stenosis of vein grafts." @default.
- W2369589039 created "2016-06-24" @default.
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- W2369589039 date "2006-01-01" @default.
- W2369589039 modified "2023-09-25" @default.
- W2369589039 title "Effect of application of Sirolimus on adventitia in preventing stenosis of vein graft" @default.
- W2369589039 hasPublicationYear "2006" @default.
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