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- W2369589177 abstract "Objective To investigate the expression of fibroblast growth factor-2(FGF-2) and topoisomerase(ToPo Ⅱ) in small cell lung cancer(SCLC) and analyze the correlation between them.Methods Immunohistochemistry(EnVision) method was used to detect the expression of FGF-2 and ToPo Ⅱ proteins in 64 cases of SCLC tissues and 20 cases of peri-cancerous tissues.The expression of ToPo Ⅱ protein and mRNA induced by FGF-2 in SCLC NCL-H446 cells were detected by Western blotting and RT-PCR.Results The positive expression of FGF-2(68.75%) and ToPo Ⅱ(79.69%) in SCLC tissues was significantly higher than 15.0% and 10.0% in pericancerous tissues,showing significant difference(P0.01).The expression of FGF-2 and ToPo Ⅱ were significantly related to clinical stages after treatment and lymph node metastasis(P0.05),but not to sex,age and smoking of SCLC patients(P0.05).A positive correlation was found between the expressions of FGF-2 and ToPo Ⅱ in SCLC(r=0.497,P0.01).The expression of ToPo Ⅱ mRNA and protein were up-regulated in NCL-H446 cells treated with FGF-2.Conclusion FGF-2 and ToPo Ⅱ may have common role pathways.FGF-2 may promote the progression of SCLC by up-regulating the expression of ToPo Ⅱ." @default.
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- W2369589177 date "2012-01-01" @default.
- W2369589177 modified "2023-09-26" @default.
- W2369589177 title "Clinical significance of FGF-2 and ToPo II protein expression in small cell lung cancer" @default.
- W2369589177 hasPublicationYear "2012" @default.
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