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- W2369594037 abstract "Objectives HLA-G is a potentially interesting molecule associated with immunosuppressive function. Here we try to define it's functions in renal transplants. Methods We survey the presence of soluble HLA-G (sHLA-G) in serial serum samples of renal transplants with ELISA tests. Results After serial analysis of the 65 patients' 330 sera,50﹪ of 26 patients in functioning group had consistent sHLA-G expression or became positive,in comparison to 20.5﹪ among 39 patients who rejected their transplants( P = 0.013). Thus sHLA-G was associated with functioning transplants. Eighty percent (77 of 96) of the HLA IgG positive sera had no sHLA-G expression,while 81.4﹪ (83 of 102) of the HLA-G(+) sera had no HLA IgG ( P = 0.005),which showed a negative association between sHLA-G and the presence of HLA IgG antibodies (which was previously been shown to be associated with failure). Conclusions In this preliminary survey,sHLA-G was found in the serum of about 30﹪ of renal transplant patients. sHLA-G had a negative association with allograft failure from chronic rejection,and a negative relationship with the production of HLA IgG antibodies. The significance of sHLA-G in renal transplants remains to be determined." @default.
- W2369594037 created "2016-06-24" @default.
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- W2369594037 date "2009-01-01" @default.
- W2369594037 modified "2023-09-27" @default.
- W2369594037 title "Soluble HLA-G expression and renal graft acceptance" @default.
- W2369594037 hasPublicationYear "2009" @default.
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