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- W2369605622 abstract "OBJECTIVE To screen relatively specifical markers in urines from renal cell carcinoma patients using surface-enhanced laser desorption and ionization time of flight mass spectrometry (SELDI-TOF-MS) ProteinChip technology. METHODS Urine samples from 40 renal cell carcinoma (RCC) patients, 40 healthy volunteers and 40 patients with other urogenital diseases were analyzed using IMAC-Cu-3 PoteinChip, which can specifically bind the metal-combining-proteins. Proteomic spectra were generated by mass spectrometry. RESULTS Four differentially expressed potentially biomarkers were identified with the relative molecular weights of 4020, 4637, 5070, and 5500. The sensitivity for diagnosing RCC was 57.5%, 66.7%, 63.7%, 65%, and specificity was 86.2%, 95%, 82.5% and 75% when the critical points were 2.0, 5.0, 5.0 and 5.0 respectively. CONCLUSIONS SELDI-TOF-MS ProteinChip technology is a quickly, easy and convenient, and high-throughput analyzing method capable of screening several relatively specific, potential biomarkers from the urines of RCC patients and had better clinical value." @default.
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- W2369605622 date "2004-07-02" @default.
- W2369605622 modified "2023-09-27" @default.
- W2369605622 title "[Screening urine markers of renal cell carcinoma using SELDI-TOF-MS]." @default.
- W2369605622 doi "https://doi.org/10.3760/j:issn:0376-2491.2004.13.011" @default.
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