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- W2369608081 abstract "Objective To investigate the effects of PG and its receptor antagonist PGL on secretion of EGF and VEGF in HT-29 cell lines in vitro.Methods The colonic cancer cell lines HT-29 was cultured in vitro and interfered with PG and PGL.The expression of EGF was detected by radioimmunoassay.The expression of VEGF was detected by ELISA.Results At the concentration of 10~(-5) mol/L and 10~(-6) mol/L,the content of the EGF in PG group was obviously higher than that in control group(P 0.01),and PG plus PGL group was less than that in PG group(P 0.01).At the concentration of 10~(-7) mol/ L,there was no difference between PG group and control group,similar result in comparison of PG plus PGL group and PG group(P 0.05).At the concentration of 10~(-5) mol/L,the content of VEGF in PG group was higher than that in control group(P 0.01),and PG plus PGL group was less than that in PG group(P 0.01).At the concentration of 10~(-6)mol/L and 10~(-7) mol/L,there was no difference between PG group and control group,similar result in comparison of PG plus PGL group and PG group(P 0.05).Conclusion It demonstrated that the PG could promote the secretion of EGF and VEGF in colonic cancer cell lines HT-29 in vitro,while PGL may inhibit its effects.Gastrin could promote the growth of colonic cancer maybe caused by stimulating the secretion of EGF and VEGF,while the PGL could inhibit partly." @default.
- W2369608081 created "2016-06-24" @default.
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- W2369608081 date "2011-01-01" @default.
- W2369608081 modified "2023-09-25" @default.
- W2369608081 title "Effects of gastrin and proglumide on the expression of EGF and VEGF in colonic cancer cell lines HT-29" @default.
- W2369608081 hasPublicationYear "2011" @default.
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