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- W2369632364 abstract "OBJECTIVE To investigate the drug resistance and resistant mechanisms of β-lactam of Pasteurella aerogenes(P.aero)from the joint fluid of a patient with knee osteoarthritis. METHODS One pathogenic bacteria isolated from the knee joint fluid of the patient with knee osteoarthritis was identified by BD's phoenixTM100,and 21 antibacterial agents were detected for susceptibility with nitrocefin test(Ncf) for β-lactamase(BLs) and a multi-disk test for the variety of BLs. RESULTS The strain was identificated by phoenixTMl00 as P.aerogenes with ID of 94%;the strain was resistant to ceftazidime and aztreonam,but susceptible to ampcillin,ampcillin/sulbactam,piperacillin,piperacillin/tazobactam,penicillins,amocillin amocillin/clavulanate,cefoxitin,and cephalothin,cefotaxime,cefepime,imipenem,meropenem,aminoglycosides,tetracyclines,chloramphenicol,polymyxin,fluoroquinolon and trimethoprim/sulfamethoxazole;During the detection of the variety of BLs,6mm for aztreonam was detected but was drug-resistant,while there were no synergy or antagonism between ceftazidime/clavulanate,ampicillin/sulbactam.Meanwhile,10 mm ceftazidime was detected as well as 14 mm ceftazidime/clavulanate,14mm cefotaxime,16mm cefotaxime/clavulanate and 28mm cefoxitin were all susceptible. CONCLUSION The clinical isolate of P.aerogenes from joint fluid of a patient with knee osteoarthritis is just resistant to some of β-lactams,thus the drug resistance is low,and the resistant mechanism of P.aerogenes is the production of BLs,being speculated to produce ESBLs by phenotype of drug resistant and ceftazidime-clavulanate synergy test." @default.
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- W2369632364 date "2012-01-01" @default.
- W2369632364 modified "2023-09-26" @default.
- W2369632364 title "Drug resistance and resistant mechanisms of Pasteurella aerogenes from knee joint fluid" @default.
- W2369632364 hasPublicationYear "2012" @default.
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