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- W2369657815 abstract "Objective:To evaluate the effect of amlodipine and sustained-release diltiazem combined medication on blood pressure,artery elasticity,and proteinuria in patients with isolated systolic hypertension(ISH).Methods:A total of 74 patients with ISH were randomly divided into 3 groups.Amlodipine group(n=25,5 mg qd);sustained-release diltiazem group(n=23,90 mg bid);and combined medication group(n=26,amlodipine 5 mg qd with sustained-release diltiazem 90 mg bid).The treatment course was 8 weeks.Blood pressure,the large and small artery elasticity indices C1 and C2,urine α1-microglobin and microalbuminuria were determined before and after the treatment.Results:After 8 weeks treatment,the systolic blood pressure(SBP)and diastolic blood pressure(DBP)were significantly decreased in all groups(P0.05).SBP had greater reduction in combined medication group than each of the single medication group(P0.05).The levels of urine α1-microglobin and microalbuminuria were decreased in all groups,while the combined medication group had the most significant reduction(P0.05).Combined medication further improved the large and small artery elasticity indices C1 and C2 than each single medication group(P0.05).There was a negative correlation between SPB,DPB and the artery elasticity(P0.05).There was a positive correlation between the reduction of proteinuria and artery elasticity indices(P0.05).Conclusion:Amlodipine and sustained-release diltiazem combined mediation indicated the additive effects to decrease blood pressure,urine α1-microglobin and microalbuminuria;it improved the arterial elasticity in patients with ISH." @default.
- W2369657815 created "2016-06-24" @default.
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- W2369657815 date "2008-01-01" @default.
- W2369657815 modified "2023-09-23" @default.
- W2369657815 title "Effect of Amlodipine and Sustained-Release Diltiazem Combined Medication on Artery Elastic Function and Proteinuria in Patients With Isolated Systolic Hypertension" @default.
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