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- W2369658520 abstract "Objective:To study the effect of Buchang Naoxintong on the injury of cerebral ischemia re-perfusion and the relation with ASIC1a.Methods: The models of transient middle cerebral artery occlusion(tMCAO) were established with the Zea-longa modified suture method.Rats were divided into Sham operation group,MCAO group and Naoxintong group.The neural function was evaluated at 1 d,3 d and 7 d after re-perfusion using Neurological Severity Score.The cerebral infarct volume was measured using TTc-dying method.The water volume in the brain was measured with dry and wet weight method.The cerebral capillary permeability was measured with EB method.Cell apoptosis was detected with TUNEL method and the protein expressions of AsICIa in ischemic brain tissue was detected with Western blotting.Results: Buchang Naoxintong could significantly improve the neurological deficits of the rats,reduce the cerebral infarct volume,lower the brain water content and the capillary permeability as well as the cell apoptosis.Byuchang Naoxintong was able to greatly abate the expression of ASICIa.Conclusion: Buchang Naoxintong has protective effect on brain tissues with re-perfusion of focal cerebral ischemia by down-grading the expression of ASIC1a." @default.
- W2369658520 created "2016-06-24" @default.
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- W2369658520 date "2013-01-01" @default.
- W2369658520 modified "2023-09-22" @default.
- W2369658520 title "Protective effect of Buchang Naoxingtong on re-perfusion of focal cerebral ischemia by down-grading the expressions of ASIC1a" @default.
- W2369658520 hasPublicationYear "2013" @default.
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