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- W2369663955 abstract "AIM: To develop a method to determining etheofazine(EDMTP) and its metabolite etheotriazene (EDMTP Ⅱ) by HPLC in human plasma. METHODS: Human plasma samples containing etheofazine(EDMTP) and its metabolite EDMTP Ⅱ after addition of internal standard (IS), was extracted with ethylacetate and separated in a reversed phase ODS column, and the detection was achieved at 345 nm by ultra violet (UV). RESULTS: The limit of detection was 0.05 mg·L -1 for both etheofazine(EDMTP) and its metabolite EDMTP Ⅱ. No potential interference was found. The method provided recoveries up to 81.42 %- 104.67 % and accepted coefficients of variation were found for both within run ( 9.95 %) and day to day ( 9.14 %) assays. CONCLUSION: This method is rapid, sensitive and simple for studying the pharmacokinetics of EDMTP and its metabolite EDMTP Ⅱ." @default.
- W2369663955 created "2016-06-24" @default.
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- W2369663955 date "2002-01-01" @default.
- W2369663955 modified "2023-09-26" @default.
- W2369663955 title "Determination of etheofazine (EDMTP)and its metabolite in human plasma by reversed-phase HPLC" @default.
- W2369663955 hasPublicationYear "2002" @default.
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