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- W2369670674 abstract "Objective: The decalcified bone matrix(DBM) combined with bone cement (BC) had been used for the repair of bone defect caused by the bone tumors treated with microwave induced hyperthermia. However the bone inductive activity could be improved when the DBM BC composite was further combined with bovine bone morphogenetic protein (bBMP). This study was to investigate the biocompatibility of the material combined with bBMP and to further offer the use for clinic. Methods: The alien canine DBM was prepared. The bBMP was extracted and mixed with DBM with the weight proportion of 1:25. Then the bBMP DBM composite was combined with BC with different weight proportion and the composite material was tested by acute and subacute toxicity test, muscle stimulation test, hemolysis and coagulation test and was examined by being implanted in the canine femur. Results: No animals died in the acute toxicity test and the body weight, red blood cells, white blood cells and hemoglobin were not effected in the subacute test. The composite material did not effect the function of hemolysis and coagulation and could be merged with the normal bone at the 6th month postoperatively. Conclusions: This composite material has excellent biocompatibility and bone inductive activity. It is favorable for the repair of bone defects with different shape and different position because it can be also modeled easily." @default.
- W2369670674 created "2016-06-24" @default.
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- W2369670674 date "2002-01-01" @default.
- W2369670674 modified "2023-09-25" @default.
- W2369670674 title "Study on Biocompatibility of Material Combined with Bone Morphogenetic Protein" @default.
- W2369670674 hasPublicationYear "2002" @default.
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