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- W2369684621 abstract "Purpose To provide an experimental model for the research of human malignant tumors of pancreas islet cells. Methods Orthotopicly transplanted the human tumor tissues into the cover membrane of pancreas in SCID mice, and its invasion metastasis and morphologic characteristics (light microscopy, electronic microscopy, immynohistochemistry) were observed. Results A model of human malignant insulinoma(HMI HMN 1) was successfully established in SCID mice, which passaged 21 generations, and a model of human malignant polypeptide tumor(IIPPT IIMN 2), which passaged 25 generations. Both the growth rate and spontaneous metastasis rate were 100% in 147 SCID mice, in which diffusely invasion of stomach and duonenum, lymph nodes and liver metastasis were present. The tranplatation tumor cells had the consistency to the original tumors of human pancreas islet cells. Conclusion The two models of human malignant tumor of pancreas islet cells in SCID mice are ideal for the research of the metastatic mechanism and therapy." @default.
- W2369684621 created "2016-06-24" @default.
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- W2369684621 date "2002-01-01" @default.
- W2369684621 modified "2023-09-22" @default.
- W2369684621 title "Immunohistochemistric and Ultrastructure Studies on the Orthotopicly Transplanted Tumors of Human Malignant Tumors of Pancreas Islet Cells" @default.
- W2369684621 hasPublicationYear "2002" @default.
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