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- W2369694739 abstract "Objective:To study the inhibitory effect of CD8α CD11c + dendritic cells (DC) on allergic asthma in schisto soma japonicum-infected mice.Methods:CD8α CD11c + DC from schistosoma japonicum-infected mice and naive were iso lated and purified using microbeads respectively.Twenty BALB/c mice were divided into four groups randomly.CD8α CD11c + DCs (5×10 5) from schistosoma japonicum-infected mice were injected into the tail vein of mice in group A.CD8α CD11c + DCs (5×10 5) of na ve were injected into the tail vein of mice in group B.Group C included simple allergic asthma rats.Rats in group D were given normal saline.One hour after injection,mice were sensitized and challenged with ovalbumin to induce asthma in groups A,B and C.After four weeks,all mice were killed,and left lungs were collected for histopathologica1 analy sis.Results:Pathology results showed that pulmonary inflammation diminished significantly in mice of group A.There were more severe lung infection in groups B and C.No lung infection was found in group D.Results of lung pathological score was significantly higher in group A than that of group D,but significantly lower than that of groups B and C (P 0.05 or P 0.01).There was no significant difference between group B and group C (P 0.05).Conclusion:CD8α CD11c + DC can significantly inhibit allergic asthma in schistosoma japonicum infected mice." @default.
- W2369694739 created "2016-06-24" @default.
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- W2369694739 date "2012-01-01" @default.
- W2369694739 modified "2023-09-26" @default.
- W2369694739 title "The Inhibitory Effect of CD8 α~-CD11c~+ Dendritic Cells on Asthma in Schistosoma Japonicum Infected Mice" @default.
- W2369694739 hasPublicationYear "2012" @default.
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