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- W2369706889 abstract "Objective:To observe the effect of Liuweidihuang decoction(LD)on expression of monocyte chemotactic protein(MCP-1) and transforming growth factor(TGF-β1) in unilateral ureter obstraction(UUO) rats.Methods:Seventy-two male Sprague-Dawley rats were randomly divided into four groups:the model group,the sham-operation group,the Enalapril group and LD group.The kidneys of rats were harversted at 7,14 and 21 d after the operation.Immunohistochemistry was used on the renal tissue for MCP-1 and TGF-β1 after7,14 and 21 day.Histological changes were also observed by HE and Masson staining.Results:Compared with those in the sham-operation group,the levels of MCP-1 and TGF-β1 expression was obviously higher than those in the other groups on day 7,14,and 21(P0.05).The MCP-1 and TGF-β1 of in LD group was higher than that in Enalapril group on day 7,14,and 21(P0.05).Conclusion:LD can decrease the expression of the UUO MCP-1 and level and TGF-β1 and reduce tubuloninterstitial injury,and LD can be an axillary drug for obstruct kidney disease." @default.
- W2369706889 created "2016-06-24" @default.
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- W2369706889 date "2009-01-01" @default.
- W2369706889 modified "2023-09-23" @default.
- W2369706889 title "Effect of Liuweidihuang Decoction on Expression of Tubuloninterstitial MCP-1 and TGF-β_1 in Unilateral Ureter Ligation Rats" @default.
- W2369706889 hasPublicationYear "2009" @default.
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