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- W2369715077 abstract "The aim of this study was to study antibacterial effects of Jin-Ying-Huang-Gui Injection(JYHGI),a Chinese herbal formula,on Staphylococcus aureus(S.aureus).JYHGI was prepared by routine method.The minimal inhibitory concentration(MIC)and minimal bactericidal concentration(MBC)of S.aureus were detected with tube double dilution method in vitro.The mice model was prepared by vena caudalis injection of S.aureus to carry antibacterial experiment in vivo.In addition,we also studied the influence of JYHGI on ultrastructure and the specific activity of succinate dehydrogenase(SDH)of S.aureus.Antibacterial activity showed that the MIC and MBC of JYHGI to S.aureus were 31.2,62.5mg·mL-1,respectively.Mortality of mice in JYHGI could significantly decrease mice mortality caused by S.aureus(P0.05).The JYHGI treated cell wall of S.aureus were covered with a large number of floc,the cells seemed to be collapsed-like,some cell wall even ruptured.The SDH specific activity of JYHGI group were significantly lower than that of control group(P0.01).It is concluded that the inhibition mechanism is that JYHGI could damage the cell wall and inhibit the enzyme system of S.aureus." @default.
- W2369715077 created "2016-06-24" @default.
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- W2369715077 date "2013-01-01" @default.
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- W2369715077 title "Antibacterial Effects of Jin-Ying-Huang-Gui Injection to Staphylococcus aureus" @default.
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