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- W2369744300 abstract "Aim To investigate the protection of oxymatrine on focal crerebral ischemic injury in rats and its mechanism of inhibition of opoptosis.Methods The method of permanent middle cerebral artery occlusion in rats(permanent middle cerebral artery occlusion,pMCAO) was adopted to establish cerebral ischemia model,Through the abdominal cavity pMCAO postoperative rats were given OMT(30,60,120 mg·kg-1).Evaluation index like cerebral infarction volume,water content and behavioral symptoms of brain were taken account in terms of OMT in cerebral ischemia neural protection.Through HE dyeing method the influence of OMT on form change and number of ischemic cortex of nerve cells was observed.Western blot was applied to detect OMT of ischemic cerebral cortex Caspase-3,Bcl-2,Bax protein level of expression.Results In rat focal cerebral ischemia body model,OMT(30,60,120 mg·kg-1) could significantly reduce the cerebellum infarction volume,water content and improve brain behavior signs(P0.01).HE dyeing results indicated: OMT could significantly increase the survival rate of nerve cells and improve the form of nerve cells.Western blot results showed: compared with false surgery group,PMCAO rats after 3,6,12,24 h,ischemic cortex Caspase-3,Bax protein expression level in 3 h began to rise and peaked at 24 h;Bcl-2 in the expression level 3h began to drop,24 h to a minimum.After given the OMT,the levels of Caspase-3,Bax protein in PMCAO rat cortex ischemia could down-regulated and the levels of Bcl-2 protein up-regulated.Conclusions The current finding provide the first evidence that OMT has a direct neuroprotective activity in cerebral ischemic neuronal injury,which is probably related to the inhibition of opoptosis by up-regulation of the levels of Bcl-2 and down-regulation of the levels of Bax and Caspase-3 singnal way." @default.
- W2369744300 created "2016-06-24" @default.
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- W2369744300 date "2013-01-01" @default.
- W2369744300 modified "2023-09-26" @default.
- W2369744300 title "Protection of oxymatrine on focal crerebral ischemic injury in rats and its mechanism of inhibition of opoptosis" @default.
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