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- W2369747666 abstract "Objective To investigate the effects of triptergium wilfordii polyglycosidium on the secretion of vascular endothelial growth factor from mononuclear-macrophages in acid oral squamous-cell carcinoma microenvironment. Methods ELISA assay was used to evaluate the effects on the secretory of VEGF in THP-1 monocytes,co-cultured with supernate of Tca8113 cells' in exponential phase of growth,in vitro acid microenvironments( p H6. 6,6. 8),treated by different concentration of TWP. Results ELISA assay showed that the secretory of VEGF of THP-1 monocytes had been significantlydecreased,after treated with TWP,co-cultured with the supernate of Tca8113 cells' in exponential phase of growth,in the identical vitro acid micro-environments( p H6. 6 or 6. 8)( P 0. 05). The ischesis ratio had been significantly increased with the raising of the densities of TWP,and presented significantly positively related to the concentration( P 0. 05). The ischesis ratio had also been significantly increased with time( P 0. 05),at p H6. 6,interfered by TWP of 5 × 10- 1μg /m L,and presented significantly positively related to time( P 0. 05). Conclusion The secretory of VEGF of the mononuclear-macrophages interfered by TWP had been significantly decreased,which were cultured in vitro acid tongue squamous-cell carcinoma microenvironment,and the ischesis ratio presented significantly positively related to the concentration and time." @default.
- W2369747666 created "2016-06-24" @default.
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- W2369747666 date "2015-01-01" @default.
- W2369747666 modified "2023-09-25" @default.
- W2369747666 title "Effects of triptergium wilfordii polyglycosidium on the secretion of vascular endothelial growth factor from mononuclear-macrophages in acid oral squamous-cell carcinoma microenvironment" @default.
- W2369747666 hasPublicationYear "2015" @default.
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