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- W2369759969 abstract "Objective To evaluate the relationship of fibrinolytic activity with hematoma enlargement in spontaneous intracerebral hemorrhage (ICH).Methods 107 patients with ICH were divided into two distinct groups according to the change of hematoma after admission: patients with hematoma enlargement and patients without hematoma enlargement. The activity of tissue-type plasminogen activator (tPA:A) and plasminogen activator inhibitor (PAI:A) in plasma were assayed by meaos of synthetic chromogenic substrate method, and the levels of plasminogen activator inhibitor-1 (PAI-1) antigen and D-dimer (D-D) were measured with an enzyme-linked immunosorbent assay (ELISA). The blood samples were obtained at 0～3 d, 4～9 d and 14～21 d after onset of the disease, respectively. All of the parameters were compared with healthy subjects. Results The tPA:A in ICH patient group at 0～3 d and 4～9 d after onset were significantly lower than those in control group (P0.05～0.01), and there was no significant difference between patent group and control group at 14～21 d. The levels of PAI:A and D-D in ICH patient group at 0～3 d and 4～9 d were significantly higher than those in control group (P0.05～0.01), and these differences became no significance at 14～21 d. During different period, the levels of PAI-1 showed no obvious change as compared with control group. All of the observing parameters presented no significant difference between the patients with hematoma enlargement and the patients without hematoma enlargement. Conclusion Our results do not support that fibrinolytic activity is associated with hematoma enlargement in spontaneous intracerebral hemorrhage." @default.
- W2369759969 created "2016-06-24" @default.
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- W2369759969 date "2007-01-01" @default.
- W2369759969 modified "2023-09-24" @default.
- W2369759969 title "Study the fibrinolytic activity of hematoma enlargement in patients with spontaneous intracerebral hemorrhage" @default.
- W2369759969 hasPublicationYear "2007" @default.
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