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- W2369761364 abstract "Objective:To explore the inhibitory effect of sulfated polysaccharides from Laminaria japonica on rat vascular smooth muscle cells(VSMCs) induced by basic fibroblast growth factor(bFGF).Methods:Rat VSMCs were obtained from the aorta of adult Sprague Dawley rats by attached explant method and identified by immunohistochemistry assay.The proliferation of VSMCs was induced by bFGF.The inhibitory effects of crude sulfated polysaccharide and its fractions on the proliferation of VSMCs were evaluated by MTT assay.Superoxide anion-scavenging activity of sulfated polysaccharides was determined by xanthine/xanthine oxidase method.Results:At concentrations ranging from 0.1 to 1 mg/mL,sulfated polysaccharides except WPS-2 revealed an obvious inhibitory effect on bFGF-induced proliferation of VSMCs.Similarly,sulfated polysaccharides except WPS-2 showed excellent superoxide anion radical scavenging capability.Conclusion:Sulfated polysaccharides except WPS-2 can dramatically inhibit the proliferation of VSMCs induced by bFGF.The functional mechanism may be related to their antioxidant activities." @default.
- W2369761364 created "2016-06-24" @default.
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- W2369761364 date "2013-01-01" @default.
- W2369761364 modified "2023-09-28" @default.
- W2369761364 title "Effect of Sulfated Polysaccharides Extracted from Laminaria japonica on Proliferation of Vascular Smooth Muscle Cells Induced by BFGF" @default.
- W2369761364 hasPublicationYear "2013" @default.
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