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- W2369764254 abstract "Objective To study the acute toxicities and anti-tumor activity of BUT-6010.Methods Anti-tumor experiment in vitro was that: nine human cancer cell lines were divided into BUT-6010 group,Cisplatin positive control group,cell control group and culture medium blank group.The inhibition rate and IC50 were studied by MTS assay;anti-tumor experiment in vivo was that: the study was divided into BUT-6010 of 10 mg/kg group,BUT-6010 of 20 mg/kg group,BUT-6010 of 30 mg/kg group,Cisplatin positive control group(2.5 mg/kg) and model group.The anti-tumor activity of BUT-6010 in vivo was observed by studying the S180 tumor-bearing mice.Results The IC50 of BUT-6010 in nine human cancer cell lines was lower than that of Cisplatin.The inhibition rate of Cisplatin(2.5 mg/kg) was 51.8%(P 0.05),the inhibition rate of BUT-6010(30 mg/kg) was 52.8%(P 0.05).Conclusion The safety and efficacy of BUT-6010(30 mg/kg) is the same as Cisplatin(2.5 mg/kg)." @default.
- W2369764254 created "2016-06-24" @default.
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- W2369764254 date "2012-01-01" @default.
- W2369764254 modified "2023-09-25" @default.
- W2369764254 title "Experimental study of anti-tumor activity of BUT-6010" @default.
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