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- W2369767500 abstract "Objective To observe the efficacy and safety of different doses of Rosuvastatin on patients with carotid atherosclerosis combined hyperlipidemia,and to conduct the comparative analysis.Methods One hundred and ten patients with carotid atherosclerosis combined hyperlipidemia were selected from May 2008 to May 2011,and randomly divided into Rosuvastatin 5 mg group(group A),10 mg group(group B),20 mg group(group C),which were served after dinner.TC,TG,HDL-C,LDL-C,carotid plaque area,neck intima-media thickness changes were compared between three groups before and after treatment,and the incidence of adverse reactions were observed.Results Three patients carotid plaque area and carotid intima-media thickness were significantly reduced(P 0.01);TC,TG,LDL-C were significantly lower(P 0.01),HDL-C were significantly higher(P 0.01).But the overall effect of group C was better than group B;group B was better than group A(P 0.05 or 0.01).Three groups of patients before and after treatment were not found significant adverse reactions.Conclusion Rosuvastatin in the treatment of carotid atherosclerosis in patients with combined hyperlipidemia has a significant effect,with good lipid-lowering,anti-inflammatory and anti-atherosclerosis effect,its efficacy has a dose-dependent,three doses of the study treatment find no significant adverse reactions,the safety deserves recognition." @default.
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- W2369767500 date "2012-01-01" @default.
- W2369767500 modified "2023-09-25" @default.
- W2369767500 title "Comparative analysis on the efficacy and safety of different doses of Rosuvastatin on patients with carotid atherosclerosis combined hyperlipidemia" @default.
- W2369767500 hasPublicationYear "2012" @default.
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