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- W2369793429 abstract "ObjectiveTo explore effects of gaseous signal molecule hydrogen sulfide (H2S) on the lung Muc5ac expression of ovalbumin (OVA)-induced asthma rats.MethodsTwenty-six healthy SD rats were randomly divided into 3 groups, asthma group (ovalbumin-induced, n=9), NaHS group(ovalbumin-induced rats treated with NaHS, n=9), and the control group(n=8). After treating for 24 hours, rats were anatomized to observe and the degree of infiltration of inflammatory cells around bronchus were scored with optical microscope. The expression of lung Muc5ac were determined by the method of immunohistochemical staining.ResultsThe score of the degree of infiltration of inflammatory cells around bronchus expressed by median were 4 in asthma group, 2 in NaHS group, and 1 in the control group. Compared with 3 groups, there were statistical significance (H=13.75, P<0.05). The protein content of lung muc5ac expressed with positive areas were (1 330.22±662.87) μm2, (715.88±282.49) μm2 and (501.75±270.58) μm2 in asthma group, NaHS group and the control group, respectively. There were significant difference compared within 3 groups(F=13.75, P<0.01).ConclusionThe expression of lung Muc5ac increases in ovalbumin-induced asthma rats. Exogenous hydrogen sulfide may play an important role in alleviate airway inflammation and protect from asthma acute break out.Key words: hydrogen sulfide; asthma; Muc5ac; ovalbumin(OVA)" @default.
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- W2369793429 date "2009-04-01" @default.
- W2369793429 modified "2023-09-23" @default.
- W2369793429 title "Effects of Exogenous Hydrogen Sulfide on the Expression of Lung Muc5ac in Ovalbumin-Induced Asthma Rats." @default.
- W2369793429 doi "https://doi.org/10.3877/cma.j.issn.1673-5250.2009.02.104" @default.
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