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- W2369816086 abstract "Objective:To investigate the expression of survivin protein and CD34 and their clinical significances in endometrial carcinoma tissue.Methods:Polymer detection system for immuno-histological staining was adopted to detect the expression of survivin protein and CD34. Microvessel densities (MVD) were counted based on CD34 marked endothelial cells of microvessels.Results:Survivin protein expressed in 44 of 60 (70.33%) cases of endometrial carcinoma, 8 of 20 (40%) cases of endometrial atypical hyperplasia, and 5 of 30 (16.67%) cases of human normal endometrium. There were significant differences among three groups (P0.05). Survivin protein expression was well correlated with FIGO stage and histological grade (P0.05). Mean±S of MVD were 34.31±12.27 in endometrial carcinoma, 21.55±10.61 in endometrial atypical hyperplasia, 8.23±2.77 in normal endometrium. There were significant differences of CD34 expression in endometrial carcinoma, endometrial atypical hyperplasia, and normal endometrium (P0.05). Positive relation existed between CD34 expression and FIGO stage (P0.05), no significant associations existed between MVD and histological grade (P0.05). Expression of survivin protein was correlated positively with MVD (P0.05). Conclusion:Survivin protein plays an important role in the onset and development of endometrial carcinoma by inhibiting the apoptosis of cancer cells and inducing the proliferation of microvessels. It is proposed that surviving protein and CD34 can be one of the parameters for prognosis in endometrial carcinoma." @default.
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- W2369816086 date "2006-01-01" @default.
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- W2369816086 title "Primary study of expression and correlationships of survivin protein and CD34 in endometrial carcinoma tissue" @default.
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