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- W2369837770 abstract "Objective To determine if propofol can affect uptake of dopamine ( DA) by dopamine transporter (DAT) . Methods Chinese hamster ovary (CHO) cells in which DAT was highly expressed were incubated with H-dopamine in the presence or absence of propofol. Uptake of H-DA was measured. The kinetic parameters Vmax and Km were calculated. Results Propofol significantly inhibited uptake of DA by DAT in CHO cells as compared with the control ( P 0.05) . Propofol-induced inhibition of dopamine uptake was associated with a decrease in Vmax from 16.67 pmol·min·10-1 cells to 11.16 pmol·min·10-1 cells although the afferent affinity between DAT and DA remained unchanged. Conclusion Propofol inhibits the transport ability of DAT in a noncompetitive fashion and reduces the reuptake of dopamine, leading to elevation in DA concentration in the synaptic cleft and potentiation of dopaminergic neurotransmission in central nervous system." @default.
- W2369837770 created "2016-06-24" @default.
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- W2369837770 date "2003-01-01" @default.
- W2369837770 modified "2023-09-25" @default.
- W2369837770 title "Effect of propofol on dopamine uptake by dopamine transporter in Chinese hamster ovary cells" @default.
- W2369837770 hasPublicationYear "2003" @default.
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