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- W2369844163 abstract "As the o-hydroxyphenyl and heterocyclic molecular fragment with a good antibacterial activity,we will be the rational combination of fire novel 2-substituted thio-5-o-hydroxyphenyl 1,3,4-oxadiazole azole compounds(1-5) were designed and synthesized.Oxadiazole intermediate was obtained by o-hydroxyphenylacetic acid as raw material,hydrazine solution and carbon disulfide under basic conditions,and finally,the target compounds were synthesized from halogenated acetophenone or halogenated phenyl amide through alkylation reaction.All compounds were confirmed by 1H-NMR、IR and elemental analysis .Antimicrobial activity tests showed that the inhibition rate of E.coli up to 91% was achieved with strong antibacterial activity at concentration of 0.01%.The inhibition rate of Staphylococcus aureus and Candida albicans were 83%,respectively.This shows that the target compounds have broad-spectrum antimicrobial activity of different strains.It is a great potential class of anti-fungal,anti-bacterial compounds.QSAR analysis showed that the phenyl ring amide substituents on the introduction of different types of antibacterial activity of compounds have important implications for the introduction of Cl,Br and other halogen atoms,can significantly enhance the antibacterial activity of compounds." @default.
- W2369844163 created "2016-06-24" @default.
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- W2369844163 date "2010-01-01" @default.
- W2369844163 modified "2023-09-23" @default.
- W2369844163 title "Synthesis and antibacterial activity of 2-substituted mercapto-5-o-hydroxyphenyl 1,3,4-oxadiazoles" @default.
- W2369844163 hasPublicationYear "2010" @default.
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