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- W2369859081 abstract "【Objective】To explore the role of CD40L-IRES2-ICOSL adenovirus vector treatment of breast cancer in mice. 【Methods】We used gene transfection techniques to construct the recombinant adenovirus vector of CD40 L, ICOSL,CD40L-IRES2-ICOSL. Select the 80 BALB/c mice, mice with MCF-7 human breast cancer cell lines to establish animal models of breast cancer were randomly divided into control group, CD40 L group, ICOSL group, CD40L-IRES2-ICOSLgroup(n= 20). To the intratumoral injection transfected with empty vector and there combinant vector of breast cancer cells after two weeks to observe the pathological changes in tumor volume, weight change and the survival time of tumor-bearing mice.【Results】CD40L group, ICOSL group, CD40L-IRES2-ICOSL group within the tumor infiltration of lymphocytes increased significantly. Compared with the control group, CD40 L group, the ICOSL group tumor growth slowed, the volume decreases, prolonged survival of tumor-bearing, there were significant differences between the two groups(P0.05),while CD40L-IRES2-ICOSL group is particularly significant(P0.01); CD40 L group and ICOSL compared no significant difference.【Conclusion】Co-expression of two gene Adv CD40L-IRES2-ICOSL treatment of mice with breast cancer animal models, can directly kill the tumor, inhibiting tumor growth, prolong the survival time of tumor-bearing animals." @default.
- W2369859081 created "2016-06-24" @default.
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- W2369859081 date "2015-01-01" @default.
- W2369859081 modified "2023-09-25" @default.
- W2369859081 title "Co-expression of pairs of genes Adv CD40L-IRES2-ICOSL experimental study of breast cancer in mice" @default.
- W2369859081 hasPublicationYear "2015" @default.
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