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- W2369859563 abstract "Objective: To explore the antitumor mechanism of topoisomerase Ⅱ inhibitors.Methods: Human acute promyelocytic cell line HL 60 cells were selected as target cells, etoposide as apoptosis inducer, and morphological observations, DNA gel electrophoresis and flow cytometic (FCM) methods were carried out to investigate apoptotic cells. Results: HL 60 cells incubated with different doses of VP 16(5 40mg/L) exhibited apoptotic morphological changes、typical“DNA ladder” lane in DNA gel electrophoresis and apparrent hypodiploid apoptotic peak(“sub G 1” peak) before “G 0/G 1” peak in FCM analysis, showing that the HL 60 cells are apoptotic. Futher investigation indicated that the apoptosis induced by VP 16 was drug dose dependent, but not apparently time dependent, and the increasing of apoptotic cells is paralleled with the decreasing of S phase cells. While HPBL cells which lacked topo Ⅱ cant be induced by VP 16 to apoptosis. Conclusion: Apoptosis induced by VP 16 is a primary mechanism in chemotherapy of leukemia and the action is mediated by topo Ⅱ." @default.
- W2369859563 created "2016-06-24" @default.
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- W2369859563 date "2000-01-01" @default.
- W2369859563 modified "2023-09-25" @default.
- W2369859563 title "APOTOSIS INDUCED BY ETOPOSIDE IN HL 60 CELLS" @default.
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