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- W2369874277 abstract "Objective: To explore the differently expressed genes between primary lesion(PL) and metastasis of tumor,and perform an initial bioinformatics analysis on a novel gene,SFT2D1,which is highly expressed in hepatic metastasis(HM).Methods: The mRNA of the tissues in PL and HM were respectively marked with Cy3-dUTP and Cy5-dUTP and hybridized with expression profile microarray,and the differently expressed genes were obtained.Initial bioinformatics analysis was performed on a novel gene named SFT2D1 without functional researches at present.Its gene structure,genome localization,the physical and chemical characteristics of the coded protein,subcellular localization,functional domain and so on were clarified,and the systematic evolution analysis was performed on the similar proteins of several species.Results: Using expression profile microarray,272 differently expressed genes were uncovered.Through efficient bioinformatics analysis,SFT2D1 protein was fundamentally identified to be a trans-membrane protein located on endoplasmic reticulum,and may involve in the synthesis and processing of metastasis related proteins.Conclusion: Microarray is an efficient and high-throughout strategy for the detection of differently expressed genes.And SFT2D1 has been thought to be a potential target for tumor metastasis researches by bioinformatics analysis." @default.
- W2369874277 created "2016-06-24" @default.
- W2369874277 creator A5011405241 @default.
- W2369874277 date "2005-01-01" @default.
- W2369874277 modified "2023-09-23" @default.
- W2369874277 title "Bioinformatics analysis of SFT2D1——a highly expressed gene in hepatic metastasis of ovarian cancer" @default.
- W2369874277 hasPublicationYear "2005" @default.
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