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- W2369885109 abstract "Aim To find novel resveratrol glycosides with differentiation effects of NB4 cells after combining administration with all-trans retinoic acid(ATRA).Methods The target compounds were synthesized by Schmidt's glycosidation method,and were screened by NBT reduction assay.Results and conclusion Ten resveratrol glycoside derivatives were synthesized,including four new compounds Res-3-Rha,Res-4'-Rha,Res-4'-Xyl,Res-4'-Ara and two firstly synthesized compounds Res-3-Xyl and Res-3-Ara,and their structures were identified by 1H-NMR and ESI-MS.The differentiation rates of groups treated with combination of ATRA with Res-3-Glc,Res-4'-Glc,Res-4'-Xyl,Res-3-Ara,Res-4'-Ara,Res-3-Rha at the concentration of 5 μmol·L-1 and 10 μmol·L-1,and resveratrol,Res-4'-Rha at the concentration of 5 μmol·L-1 were significantly higher than those treated with the same dose of ATRA alone." @default.
- W2369885109 created "2016-06-24" @default.
- W2369885109 creator A5086779479 @default.
- W2369885109 date "2010-01-01" @default.
- W2369885109 modified "2023-09-23" @default.
- W2369885109 title "Synthesis of resveratrol glycosides and their retinoic acid metabolism blocking activity" @default.
- W2369885109 hasPublicationYear "2010" @default.
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