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- W2369886729 abstract "Objective To investigate the effect of total panax notoginseng saponins(tPNS)on the proliferaˉtion,cell cycle and NF-κB activity of rabbit vascular smooth muscle cell(VSMC)in order to find out the mechanism of its action.Methods By techniques of cell culture in vitro,VSMC stimulated by fetal bovine serum were treated by tPNS in different concentration for a certain period,then the inhibitory rate of cell proliferation was meaˉsured by MTT method,cell cycle distribution and NF-κB activity of the cell were measured by Flow-Cytometry respectively.Results tPNS could obviously inhibit the proliferation of VSMC stimulated by fetal bovine serum(IC 50 value was14.8μg/ml).tPNS also could decrease S phase cells,increase G 0 /G 1 phase cells and down-regulate NF-κB activity of VSMC by concentration-dependent manner,and the results were significant compared with the control(P0.01).Conclusions tPNS could obviously inhibit the proliferation of VSMC,and regulating NF-κB activity of VSMC may be one of the mechanisms of tPNS'preventive atherosclerosis." @default.
- W2369886729 created "2016-06-24" @default.
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- W2369886729 date "2004-01-01" @default.
- W2369886729 modified "2023-09-23" @default.
- W2369886729 title "Effect of Total Panax Notoginseng Saponins on Nuclear Factor κappaB and Cell Cycle of Rabbit Vascular Smooth Muscle Cells" @default.
- W2369886729 hasPublicationYear "2004" @default.
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