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- W2369893611 abstract "OBJECTIVE To investigate the value of acute phase protein in the diagnosis and therapy for nosocomial infection monitoring. METHODS The levels of serum C-reactive protein(CRP),serum amyloid A(SAA),α_1-acid glycoprotein(AAG),and α_1-antitrypsin(AAT) were measured in 71 gynecological patients with nosocomial infection during chemotherapy,Thirty normal controls and 33 chemotherapy patient controls were detected by nephelometry and compared with white blood cell counts. RESULTS The nosocomial infection rate of chemotherapy patients was 16.7%.Main pathogens were Gram-negative bacteria(60.6%).Fungi infection rate was 19.7%.The most frequent hospital infection sites were respiratory tract,gastrointestinal tract and wound.Compared with controls,the levels of serum CRP,SAA,AAG and AAT were significantly higher in chemotherapy patients with bacteria infection(P0.01) and the indexes of detection significantly decreased after treatment(P0.01).the levels of serum SAA were significantly higher in chemotherapy patients with virus infection(P0.01).The patients with favorable prognosis had significantly lower levels of acute phase protein than those of patients with unfavorable prognosis(P0.01);compared with white blood cell count,CRP and SAA were more sensitive and specific to monitoring nosocomial infection. CONCLUSIONS Measuring the level of acute phase protein(special CRP+SAA) in gynecological patients with nosocomial infection during chemotherapy has great significance to early diagnosis,and predicting the therapeutic effects and prognosis." @default.
- W2369893611 created "2016-06-24" @default.
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- W2369893611 date "2006-01-01" @default.
- W2369893611 modified "2023-09-25" @default.
- W2369893611 title "Acute Phase Protein in Gynecological Patients with Nosocomial Infection During Chemotherapy" @default.
- W2369893611 hasPublicationYear "2006" @default.
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