Matches in SemOpenAlex for { <https://semopenalex.org/work/W2369896458> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2369896458 abstract "Objective To observe the effect of matrine on telomerase activity and apoptosis of bone marrow cells in mice exposed to low-dose radiation.Methods Mice were exposed 0.2 Gy/d irradiation by Varine 600 linear accelerator for 5 days,10 days,15 days and 20 days respectively,and sacrificed on the 1st,3rd,6th,10th,15th and 21st day after irradiation respectively.The extent of bone marrow cell proliferation were observed.Telomerase activity of the bone marrow cells was detected by telomerie repeat amplification protocol-enzyme-linked immunosorbent assay(TRAP-ELISA).The apoptosis rate was detected by flow cytometry(FCM) after marked by Annexin V-FITC and PI.Results The proliferation of bone marrow cells was obviously increased in mice within 10 days after irradiation,the telomerase activity was highly expressed,and the apoptosis was decreased(P0.05).Ten days after low-dose irradiation,the proliferation and telomerase activity were inhibited and the cell apoptosis was induced(P0.05).High dose matrine administration could significantly inhibit the high expression of telomerase and induce the cell apoptosis ten to twenty days after irradiation(P0.05).Conclusion Low-dose irradiation with the accumulative dose lower than 2 Gy can induce the high expression of mice bone marrow cell telomerase activity and inhibit the cell apoptosis.The accumulative dose higher than 2 Gy has the opposite effect.High dose matrine can inhibit the high expression of mice bone marrow cell telomerase activity,induce the cell apoptosis,and can be chosed for radioprotection." @default.
- W2369896458 created "2016-06-24" @default.
- W2369896458 creator A5040027560 @default.
- W2369896458 date "2011-01-01" @default.
- W2369896458 modified "2023-09-23" @default.
- W2369896458 title "Effect of Matrine on Telomerase Activity and Apoptosis of Bone Marrow Cells in Mice Exposed to Low-dose Radiation" @default.
- W2369896458 hasPublicationYear "2011" @default.
- W2369896458 type Work @default.
- W2369896458 sameAs 2369896458 @default.
- W2369896458 citedByCount "0" @default.
- W2369896458 crossrefType "journal-article" @default.
- W2369896458 hasAuthorship W2369896458A5040027560 @default.
- W2369896458 hasConcept C104317684 @default.
- W2369896458 hasConcept C1491633281 @default.
- W2369896458 hasConcept C153911025 @default.
- W2369896458 hasConcept C16685009 @default.
- W2369896458 hasConcept C185592680 @default.
- W2369896458 hasConcept C190283241 @default.
- W2369896458 hasConcept C203014093 @default.
- W2369896458 hasConcept C2776545273 @default.
- W2369896458 hasConcept C2780007613 @default.
- W2369896458 hasConcept C43617362 @default.
- W2369896458 hasConcept C502942594 @default.
- W2369896458 hasConcept C553184892 @default.
- W2369896458 hasConcept C55493867 @default.
- W2369896458 hasConcept C62112901 @default.
- W2369896458 hasConcept C71924100 @default.
- W2369896458 hasConcept C86803240 @default.
- W2369896458 hasConcept C88634738 @default.
- W2369896458 hasConcept C94581717 @default.
- W2369896458 hasConceptScore W2369896458C104317684 @default.
- W2369896458 hasConceptScore W2369896458C1491633281 @default.
- W2369896458 hasConceptScore W2369896458C153911025 @default.
- W2369896458 hasConceptScore W2369896458C16685009 @default.
- W2369896458 hasConceptScore W2369896458C185592680 @default.
- W2369896458 hasConceptScore W2369896458C190283241 @default.
- W2369896458 hasConceptScore W2369896458C203014093 @default.
- W2369896458 hasConceptScore W2369896458C2776545273 @default.
- W2369896458 hasConceptScore W2369896458C2780007613 @default.
- W2369896458 hasConceptScore W2369896458C43617362 @default.
- W2369896458 hasConceptScore W2369896458C502942594 @default.
- W2369896458 hasConceptScore W2369896458C553184892 @default.
- W2369896458 hasConceptScore W2369896458C55493867 @default.
- W2369896458 hasConceptScore W2369896458C62112901 @default.
- W2369896458 hasConceptScore W2369896458C71924100 @default.
- W2369896458 hasConceptScore W2369896458C86803240 @default.
- W2369896458 hasConceptScore W2369896458C88634738 @default.
- W2369896458 hasConceptScore W2369896458C94581717 @default.
- W2369896458 hasLocation W23698964581 @default.
- W2369896458 hasOpenAccess W2369896458 @default.
- W2369896458 hasPrimaryLocation W23698964581 @default.
- W2369896458 hasRelatedWork W2348747653 @default.
- W2369896458 hasRelatedWork W2351805849 @default.
- W2369896458 hasRelatedWork W2353499761 @default.
- W2369896458 hasRelatedWork W2354622340 @default.
- W2369896458 hasRelatedWork W2357488769 @default.
- W2369896458 hasRelatedWork W2359916200 @default.
- W2369896458 hasRelatedWork W2370150616 @default.
- W2369896458 hasRelatedWork W2370924325 @default.
- W2369896458 hasRelatedWork W2371021356 @default.
- W2369896458 hasRelatedWork W2378227502 @default.
- W2369896458 hasRelatedWork W2378536668 @default.
- W2369896458 hasRelatedWork W2385559656 @default.
- W2369896458 hasRelatedWork W2386321474 @default.
- W2369896458 hasRelatedWork W2387934905 @default.
- W2369896458 hasRelatedWork W2389705610 @default.
- W2369896458 hasRelatedWork W2392080789 @default.
- W2369896458 hasRelatedWork W2411531718 @default.
- W2369896458 hasRelatedWork W3030216927 @default.
- W2369896458 hasRelatedWork W3032614750 @default.
- W2369896458 hasRelatedWork W1968514653 @default.
- W2369896458 isParatext "false" @default.
- W2369896458 isRetracted "false" @default.
- W2369896458 magId "2369896458" @default.
- W2369896458 workType "article" @default.