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- W2369897418 abstract "Objective To observe the hemodynamic changes by two-dimentional color Doppler ultrasonography (2D-CDUS) and cerebral mircovascular and ultrastructure of the brain by pathology on rabbit model of unilateral carotid atherosclerosis stenosis and occlusion. Methods The rabbits were divided into the control group (n=5 , group I), the test group (n=10, groupⅡ). The control group was fed with normal diet and the test group was fed with high lipofood diet. The grafting Ameroid constrictor ring was imbeded 4 week later to establish unilateral carotid atherosclerosis stenosis and occlusion model in group Ⅱ. Ultrasonography was used to detect the changes of IMT and hemodynamic parameters of carotid pre and 2, 3, 4 weeks post Ameriod constracting ring grafted, and comparde with the control group. Then the rabbits were killed and the brain were examined by immonohistochemistry and electroscope. Results All the index in group I and in group Ⅱof 4 weeks before the ring grafted had no significant significant difference. After the ring grafted, the width of blood flow narrowed and the velocity increased. At 4 weeks post implantation, the flow velocity decreased till the disappenrance of blood flow signal and waveform, which was significantly different from the control group (P0.05). The neomicrovassels developed significantly more in group Ⅱ compared with groupⅠunder the microscope (P0.05), accompanied with the brain ischemic morphological changes in mitochondrion and endoplasmic reticulum under the electroscope. Conclusion 2D-CDUS can detect the hemodynamic changes of common carotid atherosclerosis stenosis and occlusion, real-timely, which is useful in the diagnosis of extracranial carotid diseases. The pathological techniques, especial the electroscopic examination provides the experimental basis for further clinical study on the atherosclerosis and ischemic vascular diseases." @default.
- W2369897418 created "2016-06-24" @default.
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- W2369897418 date "2009-01-01" @default.
- W2369897418 modified "2023-09-23" @default.
- W2369897418 title "Research on rabbit unilateral carotid stenotic occlusion model and cerebral microvascular ultrastructure" @default.
- W2369897418 hasPublicationYear "2009" @default.
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