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- W2369900899 abstract "Objective To investigate the effects of a wide range of concentrations of As 2O 3 malignant lymphoma cell lines. Methods Cell apoptosis situation ,cellular DNA contents and bcl 2 protein expression were determined by cell stain, TdT mediated dUTP Nick end Labeling (TUNEL) and flow cytometry. Results 0.5 μmol/L～2 0 μmol/L As 2O 3 could inhibit Raji cell growth accompanied by the appearance of morphologic characteristics of apoptosis. Number of sub G 1 cells significantly increased and bcl 2 protein expression in Raji cells was significantly down regulated assayed by flow cytometry. The relationship between bcl 2 protein and the concentrations of As 2O 3 showed a dose and time dependent effect; so did the number of sub G 1 cells. However, there was no effect of 0.5 μmol/L～4.0 μmol/L As 2O 3 on Jurkat cell.Conclusion It is found that As 2O 3 could significantly inhibit the growth of B lymphoma cell lines and induce their apoptosis." @default.
- W2369900899 created "2016-06-24" @default.
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- W2369900899 date "2001-01-01" @default.
- W2369900899 modified "2023-09-24" @default.
- W2369900899 title "STUDIES OF APOPTOSIS INDUCED IN MALIGNANT LYMPHOMA CELL LINES BY ARSENIC TRIOXIDE" @default.
- W2369900899 hasPublicationYear "2001" @default.
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