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- W2369902037 abstract "AIM: To evaluate the expression of orexin and its receptors in rat pancreatic tissue with insulin resistance.METHODS: Rat model with insulin resistance induced by high-fat diet was confirmed by euglycemic clamp.Serum glucose and insulin were measured by chemiluminescent immunoassay.The expressions of orexin gene and its receptors(OX1R and OX2R) in rat pancreatic tissue were identified by real-time PCR and Western blooding.RESULTS: After 4 weeks high-fat diet,the glucose infusion rate significantly decreased from(12.5±0.6) mg·kg-1·min-1 to(7.6±0.4) mg·kg-1·min-1(P0.05).Body weight,serum glucose and insulin increased 26%,25% and 30%,respectively(P0.05).Moreover,the expressions of orexin mRNA and protein decreased about 71% and 63%,and OX1R mRNA and protein reduced about 49% and 67% in rat pancreatic tissue with insulin resistance,respectively,compared to normal rat(P0.05).However,the expression of OX2R mRNA and protein did not decreased obviously.CONCLUSION: High-fat diet induces insulin resistance in Wistar rat.The transcription and translation of orexin and OX1R genes in rat hypothalamus are down-regulated in insulin resistance.Orexin system may play a role in insulin resistance and lipid-pancreatic island metabolism." @default.
- W2369902037 created "2016-06-24" @default.
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- W2369902037 date "2009-01-01" @default.
- W2369902037 modified "2023-09-27" @default.
- W2369902037 title "Expression and significance of orexin system in rat pancreatic tissue with insulin resistance" @default.
- W2369902037 hasPublicationYear "2009" @default.
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