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- W2369903871 abstract "SUMMARY Objective:To analyse the reason for a strange phenomenon in adriamycin entrapment by liposomes prepared by double emulsion method.Methods:PEG modified blank liposomes were prepared by different methods, and blank liposomes without PEG modification were also prepared in order to see whether the similar phenomenon would occur;different PEG adriamycin ratios and different incubation times were designed to observe their effect on absorption;mixture composed of PEG 20000 and adriamycin was dialysed to find the absorption between PEG itself and adriamycin.Results:The phenomenon was unaffected by preparation method and liposome itself, but only affected by the presence of PEG chains around PEG modified liposomes;both the PEG adriamycin ratio and incubation time affected the absorption of adriamycin to PEG;the PEG alone could absorb adriamycin well; the absorption occurred when oxytetracycline was in place of adriamycin.Conclusion:The reason for the phenomenon was the absorption of adriamycin or oxytetracycline molecules to PEG chains where multiple hydrogen bonds might be formed. It is suggested PEG modified liposomes or PEG containing carriers such as microencapsules and microspheres would increase the entrapment efficiency or carrying amount of this kind of low molecular drugs which contain a number of hydroxies or aminos." @default.
- W2369903871 created "2016-06-24" @default.
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- W2369903871 date "2002-01-01" @default.
- W2369903871 modified "2023-09-25" @default.
- W2369903871 title "The effect of PEG-modified liposomes on adriamycin entrapment" @default.
- W2369903871 hasPublicationYear "2002" @default.
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