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- W2369906783 abstract "Objective:To explore the infusion of intermittent hypoxia on p38MAPK and ultrastructure changes in marginal striatum of weanling rats and the intervention effects of apigenin.Methods:Randomly,fourty male Sprague-Dawley rats(3-week.old~4-week-old)were divided into four groups:2-weeek-IH group(IH),control group(C),apigenin+DMSO(Q)group and DMSO control(R)group.Intermittent hypoxia model was induced by an intermittent hypoxia cabin.In medial border of the striatum,the marginal division(MrD),the expression of p38MAPK mRNA and the phosphorylation levels of p38MAPK(phospho-p38)were measured by RT-PCR or Westernblot respectively.The ultrastructure of MrD was studied by electron microscope.Results:In the MrD,the expression of p38MAPK mRNA and p-p3 8 protein in IH group were respectively higher than C group(P0.01,respectively).These expressions in Q group had significantly less than in R group(P0.01,respectively).The nuclear membrane of MrD cells in IH or R groups were broken,chromatin concintration and edge accumulation and some mitochondria were enlarged and vacuoled.Conclusions:Intermittent hypoxia actived the p38MAPK signal transduction,led ultrastructure of neuron disordered in brain regions.Apigenin can partial reduce the activation of p38MAPK which may play a positive role in alleviating the cerebral tissues injury in intermittent hypoxia weanling rats." @default.
- W2369906783 created "2016-06-24" @default.
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- W2369906783 date "2008-01-01" @default.
- W2369906783 modified "2023-09-24" @default.
- W2369906783 title "The Infusion of Intermittent Hypoxia on p38MAPK and UItrastructure Changes in Marginal Striatum of Weanling Rats and the Intervention Effects of Apigenin" @default.
- W2369906783 hasPublicationYear "2008" @default.
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