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- W2369909306 abstract "Objective To investigate the expressions and significance of CD109,high molecular weight cytokeratin(HMW-CK),vimentin,p63 and antrogen receptor(AR) in basal-like breast cancer(BLBC).Methods ER and PR-negative and CK5/6 and/or EGFR-postive expression was defined as BLBC.Immunohistochemical method was used to determine the expressions of CD109,HMW-CK,vimentin,p63 and AR in 86 cases of BLBC,compared with 57 cases of luminal type and 33 cases of HER-2 over-expressed breast cancer.Results The positive rates of CD109 were 61.6%,8.8% and 9.1% in BLBC,luminal type and HER-2 over-expressed breast cancer,while HMW-CK were 90.7%,26.3% and 33.3%,and AR were 31.4%,71.9% and 42.4%.There was significant difference among them(P0.01).The positive rates of vimentin was 57.0%,42.1% and 51.5%,and p63 were 31.4%,29.8% and 24.2% respectively.The difference was not significant among them(P0.05).The expression of CD109,HMW-CK,vimentin and p63 were not correlated to age,tumor size,histological grade and lymphadenopathy.AR was correlated to histological grade in BLBC.Conclusion CD109 and HMW-CK are the specific markers for the diagnosis of BLBC,while vimentin and p63 are not.The lack of AR expression in BLBC is related to invasion of tumor and malignant phenotype." @default.
- W2369909306 created "2016-06-24" @default.
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- W2369909306 date "2012-01-01" @default.
- W2369909306 modified "2023-09-24" @default.
- W2369909306 title "Expressions of CD109,HMW-CK,vimentin,p63 and AR in basal-like breast cancer" @default.
- W2369909306 hasPublicationYear "2012" @default.
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