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- W2369909908 abstract "Objective To investigate the effects of different magnitudes of mechanical strain on expression of MMP-13/TIMP-1 mRNA in mouse osteoblast-like cells(MC3T3-E1) in vitro.Methods MC3T3-E1 cells were subjected to 0%,6%,12%,18% elongation by using multi-passage cell stress loading system simultaneously for 24h,then MMP-13/TIMP-1 mRNA in MC3T3-E1cells were detected by RT-PCR.Results Expression of MMP-13/TIMP-1 mRNA in mouse osteoblast-like cells(MC3T3-E1) significantly increased in groups under strain(6%,12%,18% elongation) in magnitude-dependent manner compared to control after mechanical strain treatment for 24h.Conclusion Different magnitudes of mechanical strain can affect expression of MMP-13/TIMP-1 mRNA in MC3T3-E1 cells in magnitude-dependent manner,which deeply affects bone remodeling." @default.
- W2369909908 created "2016-06-24" @default.
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- W2369909908 date "2006-01-01" @default.
- W2369909908 modified "2023-09-26" @default.
- W2369909908 title "Effects of different magnitudes of mechanical strain on expression of MMP-13/TIMP-1 mRNA in mouse osteoblast-like cells(MC3T3-E1) in vitro" @default.
- W2369909908 hasPublicationYear "2006" @default.
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