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- W2369910347 abstract "Objective To investigate the possible role of p38 mitogen-activated protein kinase(MAPK) in lung injury following intestinal ischemia reperfusion(II/R) in mice.Methods Intestinal ischemia/reperfusion was induced by occluding the superior mesenteric artery for 45 min followed by 6 h reperfusion.C57BL/6 mice were randomly divided into sham-operated group(sham group),II/R group and II/R plus SB239063 treatment(SB239063 group),n=6/group.SB239063(3 mg/kg),a novel second-generation p38 MAPK inhibitor,was administered intraperitoneally one hour before clamping.Pulmonary p38 MAPK and phospho-p38 MAPK protein were measured by Western blotting analysis.Gene expression of TNF-α and IL-1β in the lung was analyzed by RT-PCR.The lung pathology was observed by optical microscope.Results Compared with the sham-operated group,pulmonary p38 MAPK activation was significantly increased 6 h after II/R(P0.01),whereas SB239063 could markedly attenuate p38 MAPK activation in lung tissue(P0.05).In addition,the increased TNF-α and IL-1β mRNA levels induced by II/R in lungs were significantly blocked by inhibiting p38 MAPK activation(P0.05).SB239063 treatment ameliorated the pathologic lung injury induced by II/R.Conclusion p38 MAPK plays an important role in lung injury induced by intestinal ischemia reperfusion(II/R) in mice,and inhibition of p38 MAPK activation prevents lung injury following II/R in mice." @default.
- W2369910347 created "2016-06-24" @default.
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- W2369910347 date "2010-01-01" @default.
- W2369910347 modified "2023-10-13" @default.
- W2369910347 title "Role of p38 MAPK signaling in lung injury following intestinal ischemia/reperfusion in mice" @default.
- W2369910347 hasPublicationYear "2010" @default.
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