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- W2369914565 abstract "Objective To observe the pathologic changes and the activities alteration of protein kinase C (PKC) and extracellular signal regulated kinase (ERK) in lung tissues in diabetic rats, and to investigate the role of signal pathways in pulmonary variety in diabetic rats.Methods Diabetic model rats were induced by injected streptozotozin. After 4 weeks, we observed the pathologic changes in lungs, tested the activities of PKC and ERK by isotope in lungs of model rats, determined the expression of ERK using Western blot.Results After STZ administration for 4 weeks, we observed thickened pulmonary capillary basal lamina and increasing number of fibre in diabetes mellitus rats. The activities PKC and ERK were found increased.Conclusions Hyperglycemia protein kinase C ERK signal pathways might be involved in the pathogenesis in lung tissues in diabetic rats." @default.
- W2369914565 created "2016-06-24" @default.
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- W2369914565 date "2004-01-01" @default.
- W2369914565 modified "2023-09-25" @default.
- W2369914565 title "The alteration of extracellular signal-regulated kinase in lung tissues in diabetic rats" @default.
- W2369914565 hasPublicationYear "2004" @default.
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