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- W2369916323 abstract "Objective To investigate the release pattern of dexamethasone (DM)loaded PLGA nanoparticles in rabbit eyes. Methods DM-PLGA nanopar-ticles were prepared using a emulsification/solvent evaporation process. After intravitreal injection,DM concentration in various parts of the rabbit eye was measured on day 1,7,14 and 21 by HPLC system. Results Within the experimental duration, nanoparticles containing 50% DM produced drug concentration ranging 0.38-0.88 mg·L-1 in the chorioretina, and 1.78-85.72 mg·L-1 in the vitreous; and that produced by nanoparticles containing 20% DM ranging 0.11-0.42 mg·L-1 in the chorioretina and 0.82-26.52 nig·L-1 in the vitreous, respectively. DM concentration in the cornea and the aqueous humor were both below the limit of detection of the HPLC assay. Clinical observation showed good biocompatibility of the DM-PLGA nanoparticles. Conclusion Nanoparticles containing 50% DM exhibited the effectire dosage maintaining 3 weeks, suggesting great potential for clinical treatment of vitroretinal dis-" @default.
- W2369916323 created "2016-06-24" @default.
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- W2369916323 date "2005-01-01" @default.
- W2369916323 modified "2023-09-28" @default.
- W2369916323 title "Pharmacokinetics characteristics of dexam-ethasone loaded PLGA nanoparticles after in-travitreal injection in rabbits" @default.
- W2369916323 hasPublicationYear "2005" @default.
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