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- W2369924980 abstract "Objective To observate the effect of a bisphosphonate BM210955 (Ibandronate) on prevention against bone loss of oophorectomized rats. Methods 40 SD rats aged 10～12 months were divided into 4 groups. Bilateral oophorectomy was performed in the experiment rats. Three months later, the rats were given BM210955 in dosage of 0.5mg·kg -1 ·d -1 by gavage for 3 months. The bisphosphonate treated rats were compared with osteoporosis animal model (OP model) control group, false operation control group and OP model with nilestriol group. Results Dry bone weight, bone ash weight, bone calcium content and femur bone mineral density in OP model control group were lower than those in false operation control group, BM210955 treated OP model group and nilestriol treated OP model group (P0.02 or P0.001). The body bone mineral density was increased by 8.7% and 0.9% in BM210955 and nilestriol administration groups respectively than that in OP model control. The bone trabecular areas of vertebra and tibia were significantly higher in BM210955 or nilestriol group than that in OP model control groups (P0.001). The urinary calcium/creatinine ratio was significanly lower in BM210955 or nilestriol group than that in OP model control group (P0.001). The urinary hydroxyproline/creatinine ratio and serum alkaline phosphatase level showed a decreasing tendency in BM210955 and nilestriol group as compared with OP model control group. Conclusions The oophorectomized SD rats showed clearly osteoporosis six months after operation. BM210955 has significant therapeutic effects on the osteoporosis of rats." @default.
- W2369924980 created "2016-06-24" @default.
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- W2369924980 modified "2023-09-23" @default.
- W2369924980 title "Study on the effect of bisphosphonate (BM210955) on bone loss in oophorectomized rats" @default.
- W2369924980 hasPublicationYear "2000" @default.
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