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- W2369928130 abstract "Objective To investigate the significance and the influence of gallnut and centipede on fibroblast proliferation and collagen synthesis of the keloid-derived fibroblasts. Methods The effects of different density and different time of gallnut and centipede on the proliferation and collagen synthesis of the fibroblasts are investigated by means of MTT reaction and 3 H-proline incorporation. Light microscope (LM)and Electron microscope(EM)are employed to study the ultrastructure changes in fibroblasts after the application of gallnut and centipede. Results It is found that gallnut and centipede can inhibit the proliferation and collagen synthesis of fibroblasts in vitro (P0.01); the effect is related to dose and time.The highest rate of inhibition are respectively 89 percent and 92 percent in dose of 10?μg/ml gallnut at 72 hours and centipede at 48 hours later. The gallnut and centipede can also significantly affect the ultrastructure of fibroblasts. Conclusion Gallnut and centipede can oviously inhibit the proliferation and collagen synthesis of fibroblasts. It prooves to be a theoretical evidence for doctors to apply Chinese herbal medicine to treating hypertrophic scar and keliod." @default.
- W2369928130 created "2016-06-24" @default.
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- W2369928130 date "2003-01-01" @default.
- W2369928130 modified "2023-09-26" @default.
- W2369928130 title "Effect of gallnut and centipede on proliferation and collagen synthesis of the keloid-derived fibroblasts" @default.
- W2369928130 hasPublicationYear "2003" @default.
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