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- W2369933997 abstract "AIM To explore the effects of acidosis on the L type Ca 2+ current ( I Ca·L ) of rat ventricular myocytes. METHODS I Ca·L was recorded using whole cell patch clamp technique. Acidosis was produced either by superfusing the cells with acid solution (intracellular and extracellular acido sis) or by NH 4Cl withdrawal (intracellular acidosis). RESULTS Both types of acidosis inhibited I Ca·L markedly. In the presence of acid solution (pH 6.5 and pH 7.0), I Ca·L was decreased to (41.7±7.5)% and (65.6±6.3)% of the control ( n =5, P 0.01) respectively. Withdrawal of NH 4Cl also resulted in decline of I Ca·L to (69.4±5.8)% of the control ( n =5, P 0.01). CONCLUSION Acidosis can inhibit I Ca·L significantly and intracellular acidosis might be involved in the process." @default.
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- W2369933997 date "2001-01-01" @default.
- W2369933997 modified "2023-09-28" @default.
- W2369933997 title "Effects of acidosis on the L-type calcium current of rat ventricular myocytes" @default.
- W2369933997 hasPublicationYear "2001" @default.
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