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- W2369934534 abstract "Objective To investigate the protective effects of magnolol against sepsis-induced inflammation and intestinal dysmotility. Methods Sepsis was induced by a single intraperitoneal injection of lipopolysaccharide(LPS). Male Wistar rats were randomly assigned to one of three treatment groups:magnolol before LPS injection(LPS/Mag group); vehicle before LPS injection(LPS/Veh group); and vehicle before injection of saline(Control/Veh) group. Intestinal transit and ex vivo circular intestinal muscle mechanical activity were assessed 12 h after LPS injection. Inducible nitric oxide synthase(iNOS) mRNA in rat intestine was studied by RT-PCR 2 h after LPS injection. In addition,antioxidant activity was determined by measuring malondialdehyde(MDA) concentration and superoxide dismutase(SOD) activity in the intestine 2 h after LPS injection. Nitrogen monoxide(NO) concentration in the intestine was also measured 12 h after LPS injection. Results Magnolol significantly increased the intestinal transit and circular muscle mechanical activity in LPS-treated animals. The iNOS mRNA expression in the small intestine were significantly reduced after magnolol treatment in LPS-induced septic animals. Moreover,magnolol significantly decreased MDA concentration and increased SOD activity in the rat intestine. Magnolol also significantly decreased NO concentration in the septic rat intestine 12 h after LPS injection. Conclusion Magnolol prevented sepsis-induced suppression of intestinal motility. The potential mechanism of this benefit of magnolol appears to be associated with blocking oxidative stress and decreasing the production of NO in the intestine." @default.
- W2369934534 created "2016-06-24" @default.
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- W2369934534 date "2009-01-01" @default.
- W2369934534 modified "2023-09-26" @default.
- W2369934534 title "Magnolol Attenuats Sepsis-induced Gastrointestinal Dysmotility in Rats" @default.
- W2369934534 hasPublicationYear "2009" @default.
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