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- W2369940765 abstract "OBJECTIVE To study the protective effects of bis(7)-tacrine(B7T) on cognitive impairment and neuropathology in chronic cerebral ischemic aged rats,and analyze the correlation between improvement of cognition and enhancement of neuro-hyperplasia.METHODS 45 male twelve-month SD rats were randomly divided into ischemic group,control group and B7T-treated group,15 rats in each group.Spatial learning and memory was accessed by Morris Water Maze,immuno-histochemistry and immuno-fluorescence were employed to detect the neuron hyperplasia and apoptosis in CA1 region.RESULTS Escape latency of ischemia group rats was longer than that of control group and B7T-treated group(P0.01).Ischemic group spent less time in the platform quadrant than that of control group and B7T-treated group(P0.05).Time of ischemic group rats crossing the platform area was less than that in control group(P0.01) and B7T-treated group(P0.05).NeuN positive cells of ischemic group were significant less than those of control group(P0.01) and B7T-treated group(P0.05) in hippocampal CA1 region.Apoptosis cells of ischemia group were more than those of control group(P0.01) and B7T-treated group(P0.05).Number of NeuN positive cells was positive related to spatial memory among ischemia group,control group and B7T-treated group,number of apoptosis cells was negative correlation.CONCLUSION Spatial learning and memory of chronic cerebral ischemic aged rats was impaired,B7T can promote pyramidal cell hyperplasia and inhibit apoptosis,these were the pathological basis of cognition improvement." @default.
- W2369940765 created "2016-06-24" @default.
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- W2369940765 date "2011-01-01" @default.
- W2369940765 modified "2023-09-23" @default.
- W2369940765 title "Protective effects of bis(7)-tacrine on cognitive impairment and neuropathology in chronic cerebral ischemic aged rats" @default.
- W2369940765 hasPublicationYear "2011" @default.
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