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- W2369958844 abstract "Objective The purpose of this study was to investigate the effects of simvastatin on endothelin and nitric oxide with atherosclerosis rabbits induced by high cholesterol dieatry.Methods 42 rabbits were randomized into three groups. The one group did not receive treatments and served as normal control group, the second group were fed regular chow with cholesterol and served as a atherosclerosis group. The groups(simvastatin group) were fed the cholesterol enriched diet in conjunction with simvastatin (Zocor)in a daily oral dose. The extent of aortic atherosclerosis was measured by planimetry of the sudanophilic area.Nitric oxide(NO) and endothelins(ET) were determined by chromatometry and radioimmunoassay separately for assessment the function of endothelium.Results At the end of 8 and 12 weeks treatment, the levels of aortic atherosclerosis areas and ET in simvastatin group were less significantly than that in atherosclerosis group( P 0 01);Only at the end of 12 weeks treatment, the levels of NO in both simvastatin and atherosclerosis groups reduced significantly than that in normal control group, but there ware not different between atherosclerosis group and simvastatin group.Conclusion Simvastatin inhibited ET in atherosclerosis rabbits induced by high cholesterol dietary, which may be related to its anti atherosclerosis role." @default.
- W2369958844 created "2016-06-24" @default.
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- W2369958844 date "2002-01-01" @default.
- W2369958844 modified "2023-09-27" @default.
- W2369958844 title "The effects of simvastatin on endothelin and nitric oxide with atherosclerosis rabbits induced by high cholesterol dietary" @default.
- W2369958844 hasPublicationYear "2002" @default.
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