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- W2369960662 abstract "OBJECTIVE To investigate the action mechanism of total flavonoids fromEpimedii Folium(EF)combined with pirarubicin(THP)on osteosarcoma cells MG-63 in vitro.METHODS Four groups were set:blank control group,EF group,THP group and combination group.Cell morphologies of each group were observed under inverted phase contrast microscope.Cell inhibition rates of different concentrations were measured by CCK-8.The combination index(CI)of the two drugs was calculated and their interactions were analyzed.Cell apoptosis rates of each group were detected by Annexin V-FITC/PI double staining flow cytometry.Expressions of Caspase-3 and P21 mRNA were detected by RT-PCR and expressions of caspase-3 and p21 protein by Western blotting.RESULTS Experiment groups presented apoptosis states in different degrees.Cell proliferation inhibition rates of single drug groups increased as the drug concentration increased.Cell proliferation inhibition and apoptosis rate of combination group were significantly higher than the single drug groups.CI stayed at 0.374-0.770 when combination group inhibition rate at 10%-90%.Both EF and THP could upregulate the expressions of Caspase-3,P21 mRNA and Caspase-3,p21 protein.The joint upregulation trend was more evident.CONCLUSION EF and THP can inhibit osteosarcoma MG-63 cell activity significantly and induce cell apoptosis,and combination of the two drugs shows synergistic effects." @default.
- W2369960662 created "2016-06-24" @default.
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- W2369960662 date "2015-01-01" @default.
- W2369960662 modified "2023-09-28" @default.
- W2369960662 title "Action mechanism of total flavonoids fromEpimedii Foliumcombined with firarubicin on osteosarcoma" @default.
- W2369960662 hasPublicationYear "2015" @default.
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