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- W2369964369 abstract "Objective To explore metallothionein-1F gene expression in human normal hepatic cell exposed to arsenic compounds. Methods cDNA was cloned by SMART method. Bioinformatics was utilized to analyze the homology and chromosomal localization of cloned gene, the structure of gene, encoding protein and trans-membranous information of the protein. Metallothionein-lF gene expression was determined by cDNA microarrays while L-02 cell line was treated in arsenite. Results Metallothionein-1F cDNA gene was cloned and located in the chromosome 16q13. It was found that metallothionein-1F gene could cross the biologic membrane according to bioinformatics analysis. Metallothionein-1F gene expression up-regulation in human normal hepatic L-02 cell line treated with arsenite was determined by cDNA microarrays. Conclusions Human metallothionein-1F gene is found to be an arsenic-related gene, which may play a vital role in the metabolism of arsenic compounds at early stage." @default.
- W2369964369 created "2016-06-24" @default.
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- W2369964369 date "2006-01-01" @default.
- W2369964369 modified "2023-09-23" @default.
- W2369964369 title "Study on the interaction of human metallothionein-1F cDNA gene with arsenic compounds" @default.
- W2369964369 hasPublicationYear "2006" @default.
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