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- W2369964637 abstract "Objective To observe the effect of basic fibroblast growth factor (bFGF) on cell apoptosis and the expression of correlative genes and to study the molecular mechanism of the protective effects of bFGF against spinal cord injury.Methods After tractive spinal cord injujry of T13-L2 and P1-N1 wave was decreased to 70% of the baseline mornitored by cortical smatosensory evoked potential,a thin plastic tube was situated in subarachnoid space below the injured level.In the treatment group,20 μl (20 μg) bFGF solution was infused via the thin tube at once,1,2,3,4,8,12 and 24 h after injury respectively.The saline-treated rats were subjected to the infusion of the equal volume of normal saline at the same time points.The rats were killed on the 6 h,1,4,7,14,21 day postoperatively (n=4 in each time point).The cell apoptosis and the expression of p53,bax and bcl-2 genes were detected.The functional recovery of spinal cord was examined by electrophysiological technique.Results Four,7,14 and 21 days after injury,the number of the TUNEL staining positve cells in the treatment group was less than in control group (P 0.01).Immunohistochemical staining revealed that the expression of p53 and bax proteins was lower,and bcl-2 was higher in the treatment group than in control group in 4,7,14,21 days after injury (P 0.01).Neuroalogical function recovery had a significant difference between the treatment group and control group (P 0.01).Conclusion bFGF can inhibit the cell apoptosis through inhibiting the expression of bax and p53 proteins and promoting the expression of bcl-2 protein so as to protect injured spinal cord,which may be one of the protective mechanisms of bFGF against spinal cord injury." @default.
- W2369964637 created "2016-06-24" @default.
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- W2369964637 date "2005-01-01" @default.
- W2369964637 modified "2023-09-26" @default.
- W2369964637 title "Effect of bFGF on the cell apoptosis and correlative gene expression after tractive spinal cord injury in rats" @default.
- W2369964637 hasPublicationYear "2005" @default.
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